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Please use this identifier to cite or link to this item:
http://hdl.handle.net/10447/44555
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| Type: | Proceedings (atti dei congressi) |
| Citation: | Blanda, V., Albanese, I., La Farina, M., Sireci, G., Agnone, A., & Torina, A. (2010). Babesia bigemina Apical Membrane
Antigen-1: features of the gene and
predictive information of the protein from
Italian strains. In “Excerpts from DBCS” VII Congresso Nazionale del Dipartimento di Biologia Cellulare e dello Sviluppo (pp.34-34). Palermo : Università degli Studi di Palermo. |
| Authors: | Blanda, V; Albanese, I; La Farina, M; Sireci, G; Agnone, A; Torina, A |
| Title: | Babesia bigemina Apical Membrane
Antigen-1: features of the gene and
predictive information of the protein from
Italian strains |
| Abstract: | Babesia bigemina is a tick-borne haemoparasite
affecting cattle in different parts of the world. One of
the few antigens characterized in this species codifies
for the Apical Membrane Antigen 1 (AMA-1), a transmembrane
protein recently identified.
In this work, we characterized the ama-1 gene from four
Italian B.bigemina strains, two obtained from Ragusa,
Sicily (ITA1 and ITA3), one obtained from Benevento,
Campania (ITA2) and one coming from Perugia,
Umbria (ITA4). Italian sequences were compared to the
Australian strain, whose sequence is available in the
Sanger Institute web site, and to some strains coming
from different parts of the world.
This study provides useful information on the features
of B.bigemina AMA-1 gene from Italian strains of the
parasite and some predictive information of the protein
obtained by bioinformatics. A comparison among
Italian strains of B.bigemina showed a very high degree
of both nucleotide and aminoacidic identity. The gene
resulted highly conserved among Italian and foreign
strains and the protein was included in the AMA-1
family. By the means of bioinformatics it was possible
to compare some features of B.bigemina AMA-1 protein
with the already characterized Plasmodium falciparum
orthologue. Predictive results show that a structural and
thus functional homology between B.bigemina and
P.falciparum AMA-1 can be supposed. Moreover
several putative antigenic peptides were detected and
they could be used for investigations about the
recognition by specific antibodies. These data put the
basis for a further study on B.bigemina AMA-1 antigen. |
| Keywords: | Babesia bigemina, AMA-1 |
| Creation Date: | Feb-2010 |
| Conference Name: | VII Congresso Nazionale del Dipartimento di Biologia Cellulare e dello Sviluppo |
| Conference Place: | Palermo |
| Conference Date: | 17-18 dicembre 2009 |
| Conference Number: | VII |
| Type detail: | 10 - Abstract di Comunicazioni o Poster di Congressi nazionali pubblicati (anche on line) |
| URL: | http://www.unipa.it/dipbio/congresso2009/congresso2009.html |
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Files in This Item:
| File |
Description |
Size | Format | Accessibility |
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| DBCS 2009 p. 34.pdf | Abstract poster | 12,01 kB | Adobe PDF | |
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